L-type Ca2+ channel blocker inhibits cognitive deficits and mossy fiber sprouting following pilocarpine seizures in immature mice
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چکیده
منابع مشابه
Pii: S0306-4522(00)00188-3
Behavioral and cognitive deficits are one of the most frequent sequelae of childhood epilepsy. Accumulating evidence indicates that epilepsy induces aberrant development of the mossy fibers in the hippocampus, the region that is commonly accepted to play a key role in learning and memory. We have therefore proposed that such abnormal maturation of the central nervous system may cause the advers...
متن کاملMossy fiber sprouting in rats hippocampus of subclinical seizures following hypoxic brain injury
1 Department of Neurology, Luzhou Medical College, Luzhou, 646000, China 2 Center for Nuclear Receptors and Cell Signaling, University of Houston, 3605 Cullen Blvd, Houston, TX 77204, USA 3 Department of Neurology, The first affiliated hospital of Chongqing medical university, Chongqing, 40016, China 4 Department of otolaryngology, Guizhou Provincial People's Hospital, Guiyang, 550002, China 5 ...
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The oomycete vegetable pathogen Phytophthora capsici causes significant losses of important vegetable crops worldwide. Calcium and other plant nutrients have been used in disease management of oomycete pathogens. Calcium homeostasis and signaling is essential for numerous biological processes, and Ca(2+) channel blockers prevent excessive Ca(2+) influx into the fungal cell. However, it is not k...
متن کاملLovastatin Modulates Glycogen Synthase Kinase-3β Pathway and Inhibits Mossy Fiber Sprouting after Pilocarpine-Induced Status Epilepticus
This study was undertaken to assay the effect of lovastatin on the glycogen synthase kinase-3 beta (GSK-3β) and collapsin responsive mediator protein-2 (CRMP-2) signaling pathway and mossy fiber sprouting (MFS) in epileptic rats. MFS in the dentate gyrus (DG) is an important feature of temporal lobe epilepsy (TLE) and is highly related to the severity and the frequency of spontaneous recurrent ...
متن کاملMossy fiber sprouting, hippocampal damage and spontaneous recurrent seizures in pentylenetetrazole kindling rat model.
AIM The aim of this study was to determine the correlations among hippocampal damage, spontaneous recurrent seizures (SRS), and mossy fiber sprouting (MFS) using pentylenetetrazole (PTZ) kindling model. METHODS Chronic epileptic model was established by administration of PTZ. Behaviour and EEG seizure activity were recorded. Rats' hippocampus were analyzed with haematoxylin and eosin (H&E) st...
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ژورنال
عنوان ژورنال: Japanese Journal of Pharmacology
سال: 1998
ISSN: 0021-5198
DOI: 10.1016/s0021-5198(19)40361-2